Oreganol P73 formula
Klinička ispitivanja Oreganol P73 formule ulja divljeg origana su započeta 2001 godine, na Džordžtaun univerzitetu u Vašingtonu. Od tada je urađen veliki broj studija kojima je potvrđeno da Carvaxyl deluje antimikrobno, antizapaljenski i antioksidantno.


Antimikrobno dejstvo
Antimikrobno dejstvo Carvaxyl-a inhibira rast i razmnožavanje preko 30 vrsta mikroorganizama (bakterija, virusa, parazita i gljivica). Antibakterijsko dejstvo se ostvaruje zbog sposobnosti Carvaxyl-a da prodre kroz ćelijsku membranu bakterije i naruši njen integritet. Studije su pokazale da kada bakterijska ćelija dođe u kontakt sa uljem od divljeg origana, menja se PH vrednost unutar bakterije, čime se ugrožava njen metabolizam i sposobnost replikacije.*2


Antinflamatorno dejstvo
Antinflamatorno dejstvo Carvaxyl-a sadrži supstancu Beta-Caryophyllin koja inhibira zapaljenja*3 i pokazao se efikasnim kod sezonskih alergija, reumatoidnog artritisa, bronhitisa, upale desni, bolova u mišićima, psorijaze, seboreje i rozacee.


Antioksidativno dejstvo
Antioksidativno dejstvo Carvaxyl-a štiti ćelije od dejstva slobodnih radikala koji oštećuju ćelije i smatraju se jednim od glavnih uzročnika zapaljenskih bolesti, ateroskleroze, kardiovaskularnih i malignih bolesti. *3,4

Reference
*1 Effects of Essential Oils and Monolaurin on Staphylococcus aureus: In Vitro and In Vivo Studies Vijaya Manohar,1 Cass Ingram,2 Judy Gray,2 Nadeem A. Talpur,1 Bobby W. Echard,1 Debasis Bagchi3 and Harry G. Preuss1 1Department of Physiology and Biophysics, GeorgetownUniversity Medical Center, Washington, DC; 2North American Herbs and Spices, Waukeegan, IL; 3Department of Pharmacy Sciences, Creighton University School of Pharmacy and AHP, Omaha, NE, USA, 2001
*2A study of the minimum inhibitory concentration and mode of action of oregano essential oil, thymol and carvacrol. Lambert RJ, Skandamis PN, Coote PJ, Nychas GJ. J Appl Microbiol. 2001 Sep;91(3):453-62.
*3Antiiflamatory and anti-allergy efects of RA, inhibition of seasonal allergic rhinosinusitis and its mechanisam, Osakabe N. Biofactors 21 (1-4): 127-131; 2004
*4Antioxidant activity and phenolic compounds in selected herbs, Zhang XL1, Guo YS1, Wang CH1, Li GQ1 Food Chem 49(11):5165-70, 2001
*5Minimum Inhibitory Concentrations of Herbal Essential Oils and Monolaurin for Gram-Positive and Gram-Negative Bacteria,Harry G. Preuss, Bobby Echard, Mary Enig, Itzhak Brook,cThomas B. Elliott,
Department of Physiology and Biophysics, Georgetown University Medical Center,Washington, DC 20057; Enig Associates, Silver Spring, MD 20904; Armed Forces, Radiobiology Research Institute, Bethesda, MD 20889
*6In Vitro Antibacterial Activity of Essential Oils against Streptococcus pyogenes
Julien Sfeir, 1 Corinne Lefrançois, 1 , 2 Dominique Baudoux, 3 Séverine Derbré, 4 ,* and Patricia Licznar 1 Evid Based Complement Alternat Med. 2013; 2013: 269161. Published online 2013 Apr 11. doi: 10.1155/2013/269161 PMCID: PMC3638616
*7Virucidal Eectivness test, Coronavirus,M. Khalid Ijaz, DVM, Ph.D. MICROBIOTEST, INC. 105B Carpenter Drive Sterling, Virginia 20164 LIN 514-101
*8Phenolic compounds from Origanum vulgare and their antioxidant and antiviral activities.Zhang XL1, Guo YS1, Wang CH1, Li GQ1, Xu JJ1, Chung HY2, Ye WC1, Li YL3, Wang GC4. Food Chem. 2014;152:300-6. doi: 10.1016/j.foodchem.2013.11.153. Epub 2013 Dec 1.
*9The antibacterial activity of oregano essential oil (Origanum heracleoticum L.) against clinical strains of Escherichia coli and Pseudomonas aeruginosa; Sienkiewicz M1, Wasiela M, Głowacka A. Med Dosw Mikrobiol. 2012;64(4):297-307.
*10Chemical compositions and antibacterial effects of essential oils of Turkish oregano (Origanum minutiflorum), bay laurel (Laurus nobilis), Spanish lavender (Lavandula stoechas L.), and fennel (Foeniculum vulgare) on common foodborne pathogens. Dadalioglu I1, Evrendilek GA.2004
*11Antifungal activities of origanum oil against Candida albicans
Vijaya Manohar,1 Cass Ingram,2 Judy Gray,2 Nadeem A. Talpur,1 Bobby W. Echard,1 Debasis Bagchi3 and Harry G. Preuss1 1Department of Physiology and Biophysics, GeorgetownUniversity Medical Center, Washington, DC; 2North American Herbs and Spices, Waukeegan, IL; 3Department of Pharmacy Sciences, Creighton University School of Pharmacy and AHP, Omaha, NE, USA, 2001
*12Oregano kills Giardia intestinalis trophozoites in vitro: antigiardiasic activity and ultrastructural damage.Ponce-Macotela M1, Rufino-González Y, González-Maciel A, Reynoso-Robles R, Martínez-Gordillo MN. Parasitol Res. 2006 May;98(6):557-60. Epub 2006 Jan 20.
*13Inhibition of enteric parasites by emulsified oil of oregano in vivo.
Force M1, Sparks WS, Ronzio RA. Phytother Res. 2000 May;14(3):213-4.